WELCOME TO OUR RESEARCH GROUP....
Research interests and some accomplishments:
Computer modeling of chemical,
biological, and medicinal data: Data science; computational
(bio)chemistry; disease models; structure, function, and evolution
of proteins; physical and (bio)inorganic
chemistry. Applications: To understand pathogenicity of
diseases, with recent emphasis on Alzheimer's
Disease, and to design molecular systems of
interest and value.
Some main findings:
|Dec 2021: Our analysis
and review of the structural biology of the
SARS-CoV-2 spike protein is now pubished in ACS
|June 2021: Our review
summarizing the FIST model of familial Alzheimer's
disease in press in WIRES Computational molecular
|Apr 2021: Our new method
- SimBa - for computing protein stability effects of
mutations is published.
|Feb 2021: Our study
investigating precision in protein stability calculation
out (with Prof Blundell @ Cambridge)
|Jan 2021: Our new
computational explanation of Alzheimer drugs published
|Aug 2020: Our
collaboration with Prof Blundell @Cambridge on protein
stability models is now published in JCIM
|March 2020: Our new
paper on protein cryo-EM effects out in PCCP
|January 2020: Welcome to
Octav Caldaruru, Ph.D.
who will work on protein stability.
|January 2019: Welcome to
Kaylanashis Jana, Ph.D.
who will work as a postdoc on protein thermostability and force field balance.
|June 2018: Welcome to
Budheswar, who will work as a postdoc on predicting
Alzheimer's disease-causing mutations
|May 2018: Humble thanks to DFF and the Danish taxpayers for supporting our project on developing new protein stability prediction tools|
|May 2018: Kasper
silently celebrates his 100th review report for ACS in
the Paragon Plus System.
|April-May 2018: Kasper
is on family leave from work.
|Feb 1, 2018. Ning Tang
joins as DFF postdoctoral fellow working on new medicine
targeting gamma secretase in Alzheimer's disease.
|Jan 1, 2018. Rukmankesh
will join our group to study laccases in collaboration
with Prof. Anne Meyer, DTU Chemical Engineering -
|Dec 12, 2017. Arun
defends his ph.d. thesis on proteins in Alzheimer's
|Dec 7, 2017. NNF awards us funding for our project that will explore the causes and disease properties of mutations in Alzheimer's disease. Thanks!|
|July 4, 2017. Kasper speaks at the EICC4 conference|
|May 8, 2017. Kasper will speak at the Danish Annual meeting for Neuroscience|
|May 8, 2017. DFF funds
our research into the mechanism and new treatments
targeting the protein gamma secretase (commence 2018)
|March 2017. Review of heme's amazing chemical properties and role in life is out.|
|Feb 2017. Benchmarking DFT for gold: First detailed benchmark of DFT's ability to describe diverse chemical bonds to gold|
|Jul 2016. Kasper
speaks at the ICPP
conference in Nanjing, China, on heme
|Jun 2016. Loss
of function in Alzheimer's Disease. A
comprehensive explanation why current clinical trials
|Apr 2016. Protein stability effects are universal and can predict stabilities of protein variants relevant to protein engineering and evolution.|
|Feb 2016. The general
mess of Aβ. New
meta-analysis shows no relationship between cell
and mouse data and clinical outcome, i.e. do not reflect
aging human AD.
|Sep 2015. The quest for the structure of β-amyloid (new work published in ChemPhysChem)|
|Aug 2015. Speaking
at the ECOSTBio meeting in Belgrade, Aug 24-25.
|July 2015. Speaking at the ICCB conference in Kauai, Hawaii, July 2 to 6.|
|June 2015. EMBO neuro- degeneration meeting in Heidelberg June 14-17.|
|March 2015. Molecular Causes of ALS: Coupling protein energy to real patient data.|
|Feb 2015. New mechanism of laccase inhibition: impairing reorganization energies.|
|Nov 2014. New patent WO2014167112 for synthesizing sugars|
|Nov 2014. First relation between patient data and chemical properties of genetic variants causing Alzheimer's disease|
|Oct 2014. Søren Brander defends his Ph.D. Congratulations!|
|Sep 2014. Arun joins our group as a ph.d. student to work on proteins involved in Alzheimer's disease.|
|Dec 2013. Kasper joins the Management commitee of the COST action on spin states in biochemistry and technology|
|Jun 2013. Pouria Dasmeh successfully defends his Ph.D. Congratulations!|
|Dec 2012. Our research is described in the Danish newspaper Politiken.|
|Oct 2012. New review in Chemical Reviews on "Bioinorganic Chemistry of Alzheimer's Disease"|
|Sep 2012. Kasper speaks at the CECAM workshop in Zaragoza, Sep 18-21.|
|Copyright 2014. Kasper P. Kepp.|