Medicinal
and Molecular Biochemistry |
|
The
zinc cascade of Alzheimer's Disease
identifying new approaches and targets for
treating the disease
|
The
"broad
crossing mechanism" of oxygen binding and
activation by heme, crucial to all life on
this planet but formally forbidden by
quantum mechanics (together with Ulf Ryde,
Lund University)
![]() K. P. Kepp, Coordination Chemistry Reviews, 2017 "Heme: From quantum spin crossover to oxygen manager of life" |
Presenilins:
The dynamic mechanism of presenilin, the main genetic risk factor of familial Alzheimer's disease ![]() A. K.
Somavarapu, K.
P. Kepp*,
Neurobiol.
Disease 2016,
89, 147-156. "The
dynamic
mechanism of
presenilin-1
function:
Sensitive gate
dynamics and
loop
unplugging
control
protein access"
A. K. Somavarapu, K. P. Kepp*, J. Neurochem. 2016, 137, 101-111. "Loss of stability and hydrophobicity of presenilin 1 mutations causing Alzheimer's Disease" |
The
loss of function theory of Alzheimer's
disease![]() K. P. Kepp*, Progress in Neurobiology, 2016, 143, 36-60. "Alzheimer’s disease due to loss of function: A new synthesis of the available data" |
N. Tang, K. P. Kepp*, J. Alzheimer's Dis. 2018, 66, 3, 939-945, "Aβ42/Aβ40 Ratios of Presenilin 1 Mutations Correlate with Clinical Onset of Alzheimer’s Disease" K. P. Kepp*, J. Alzheimer's Dis., 2017, 55, 2, 447-457. "Ten Challenges of the Amyloid Hypothesis of Alzheimer's Disease" |
|
Fundamental Physical Inorganic Chemistry | |
The thermochemcial spin series (complements the spectrochemical series of inorganic chemistry) ![]() S. R. Mortensen, K. P. Kepp*, J. Phys. Chem. A 2015, 119, 4041-4050. |
Oxophilicity and thiophilicity scale ![]() K. P. Kepp*, Inorganic Chemistry, 2016, 55, 18, 9461-9470. "A Quantitative Scale of Oxophilicity and Thiophilicity" |
K. P. Kepp*, Transition Metals in Coordination Environments, 1-33 (2019), Springer. "The Electronic Determinants of Spin Crossover Described by Density Functional Theory" M. T. Nielsen, K. A. Moltved, K. P. Kepp*, Inorg. Chem. 2018, 57, 7914-7924, "Electron Transfer of Hydrated Transition-Metal Ions and the Electronic State of Co3+ (aq)" |
|
Density Functional Theory | |
Mapping
the direction and magnitude of systematic
effects in theoretical chemistry to obtain
chemical accuracy
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